Fig. 6. Proposed mechanisms of action for miRNA-22 in females. Deletion of miRNA-22 attenuated body weight gain, adiposity, and prevented obesogenic diet-induced insulin resistance and dyslipidemia in females. Moreover, deletion of miRNA-22 and obesity induced cardiac hypertrophy in females. The increased mRNA levels of Yap1, Egfr and Tgfbr1 in hearts induced by miRNA-22 deletion was prevented by obesogenic diet.